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Immunotherapy vs Chemotherapy: How Are They Different?

By Dr. Varun Rajan · 17 Oct 2026

Immunotherapy vs Chemotherapy: How Are They Different?

Immunotherapy and chemotherapy are two very different ways of treating cancer.

How does chemotherapy work?

It uses drugs that kill fast-dividing cells, including cancer cells, acting throughout the body.

How does immunotherapy work?

It helps the patient's own immune system find and attack cancer — including checkpoint inhibitors and cellular therapies like CAR-T.

Which is better?

Neither is universally better — it depends on cancer type, stage, biomarkers and health. They are sometimes combined.

Are side effects different?

Yes. Chemotherapy often affects blood counts, hair and digestion; immunotherapy can cause immune-related inflammation. Both are managed by the team.

Who can advise me?

Dr. Varun Rajan, Medical Oncologist at Medical Trust Hospital, Kochi.

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